6/10/2023 0 Comments Antidote for vitamin k toxicity![]() ![]() ![]() ![]() They include yellow/white phosphorous, metal phosphides, and 4-hydroxycoumarin derivatives. In conclusion, the authors recommended vitamin K: therapy, 2 mg/kg by tablet or injection, daily for 3 weeks in cases of known or suspected brodifacoum poisoning in dogs. Newborn babies are given vitamin K injections to prevent a serious disease called haemorrhagic disease of the newborn (. Moderately toxic: LD 50 ranging from 50 to 500 mg/kg Less toxic: LD 50 500 mg/kg In this review, we shall focus on the three main classes of rodenticides, commonly incriminated as agents of poisoning in the Indian subcontinent. The remaining 7 dogs showed various signs of anticoagulant poisoning 4 to 8 days after dosing and they received a 5 day course of vitamin Kr After this period one dog had a transient rise in its P time but this returned to normal without treatment, while another dog was treated on days 16,20,29 and 30. Two dogs died suddenly without pre¬monitory clinical signs of poisoning. Patients who have no therapeutic requirement for anticoagulation are given 5mg of vitamin K BD for 2 days and medically cleared. Nine dogs received vitamin K: (2 mg/kg by intramuscular injection) when clinical signs of anticoagulant poisoning were observed. Four dogs were not given further vitamin Kj and two of these died of acute blood loss from an intrathoracic hemorrhage. ![]() It was necessary to give further doses of vitamin Kj to most of the dogs for up to 2 weeks after the first treatment period to reduce their P times to normal levels (seconds). Eleven were immediately treated with vitamin K: daily for 5 days, either by intramuscular injections (2 mg/kg) or oral tablets (1 mg/kg). which is usually given as an antidote for 1 to days. Twenty dogs received a potentially lethal (15 mg/kg) dose of brodifacoum, a halogenated coumarin-type anticoagulant poison. Vitamin K for dogs is considered safe and has no known toxicity associated with high doses of it in its K1 or K2 forms. Vitamin K antagonists (e.g., warfarin Coumadin), unfractionated heparin, low-molecular-weight heparin (LMWH), and direct oral anticoagulants are commonly used for the prevention and treatment. ![]()
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